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目的:观察多囊卵巢综合征(PCOS)不孕患者采用中西医结合治疗的临床效果及其安全性。方法:选取我院收治的60例PCOS不孕患者为研究对象,将所有患者根据随机数字表法分为对照组(给予克罗米芬胶囊以及绒毛膜促性腺激素(HCG)治疗)和观察组(在对照组治疗基础上加用我院自拟的温宫育子汤加减治疗),对比观察两组患者治疗1个疗程后的临床疗效、治疗前后各项生殖内分泌激素水平变化、排卵率、妊娠率以及不良反应发生情况。结果:观察组治疗总有效率(96.7%)明显高于对照组(63.3%),差异对比具有统计学意义(P<0.05);两组患者治疗前,T、LH、FSH、LH/FSH等各项生殖内分泌激素水平并没有很明显差异(P>0.05),经治疗后,两组各项生殖内分泌激素指标水平较治疗前均有所下降(P<0.05),但观察组患者下降幅度更为显著(P<0.05);经过半年时间跟踪随访,结果发现观察组排卵率(76.7%)、妊娠率(53.3%)明显高于对照组50%、23.3%,差异对比具有统计学意义(P<0.05);两组患者在用药治疗期间并未出现明显的不良反应,两组患者的肝肾功能也未出现明显损害。结论:PCOS致不孕症患者采用中西医结合治疗的临床疗效显著,可有效调节患者机体内分泌情况,提高患者周期排卵率以及妊娠率,且不良反应较轻,值得在临床上进一步推广、应用。
Objective: To observe the clinical effect and safety of combined treatment of Chinese and Western medicine for patients with polycystic ovary syndrome (PCOS) infertility. Methods: Sixty infertile women with PCOS admitted to our hospital were enrolled in this study. All patients were divided into control group (treated with clomiphene capsules and human chorionic gonadotropin (HCG)) and observation group according to random number table Control group based on the treatment plus our own Wen Gong Yu Zi Decoction treatment), compared two groups of patients after treatment of a course of clinical efficacy, before and after treatment of various reproductive hormone levels, ovulation, pregnancy rates and Adverse reactions occurred. Results: The total effective rate of observation group (96.7%) was significantly higher than that of control group (63.3%), the difference was statistically significant (P <0.05); before treatment, T, LH, FSH, LH / FSH The reproductive endocrine hormone levels and there was no significant difference (P> 0.05), after treatment, the two groups of reproductive endocrine hormone levels were lower than before treatment (P <0.05), but the decline in the observation group was more (P <0.05). After six months of follow-up, the ovulation rate (76.7%) and pregnancy rate (53.3%) in the observation group were significantly higher than those in the control group (50.3% and 23.3%, respectively) <0.05) .There was no obvious adverse reaction between the two groups in the medication treatment, and the liver and kidney function of the two groups did not show obvious damage. CONCLUSION: The clinical efficacy of PCOS-induced infertility patients treated with combination of TCM and Western medicine is significant, which can effectively regulate the endocrine status of patients and improve the ovulation rate and pregnancy rate of patients with less adverse reactions. It is worth further clinical application.