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本文研究用氢化大豆磷脂制备的双氯灭痛缓释片中药物的释放,通过检测服用双氯灭痛缓释片或常规片后尿中药物的排泄量,探讨双氯灭痛在人体的吸收情况。材料和方法: 双氯灭痛和氢化大豆磷脂两者粒度均小于74μm。双氯灭痛常规片(25 mg/片)为市售品。取4g双氯灭痛和16 g氢化大豆磷脂混匀,加入乙醇后减压抽干,得固体物碾碎,收集149～350μm粒度的药粉制备缓释片,片重251.2±2.4 mg,直径8mm,厚度3mm,含量52.3±1.1 mg/片。双氯灭痛缓释片和常规片的体外溶出试
This article studies the release of diclofenac sustained-release tablets prepared with hydrogenated soybean phospholipid, and explores the absorption of diclofenac in the human body by measuring the excretion of drugs taking diclofenac sustained-release tablets or conventional tablets. MATERIALS AND METHODS: Diclofenac and hydrogenated soya lecithin both had particle sizes less than 74 μm. Diclofenac conventional tablets (25 mg / tablet) for the commercial products. Take 4g diclofenac and 16g hydrogenated soybean phospholipid mixed, add ethanol decompression drained, the solid was crushed to collect 149 ~ 350μm particle size powder prepared sustained release tablets, weight 251.2 ± 2.4 mg, a diameter of 8mm, a thickness of 3mm , Content 52.3 ± 1.1 mg / tablet. In vitro dissolution test of diclofenac sustained release tablets and conventional tablets