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ATP 治疗室上性心动过速早在1955年已有报道。近年有人对婴儿阵发室上性心动过速静脉注射ATP,并与异搏停和洋地黄作比较,认为 ATP 和异搏停是快速终止阵发性室上性心动过速的首选药物。本文进一步探讨 ATP-2Na 对各类阵发性室上性心动过速的作用部位、疗效及对存在旁路施行心室起搏病人的电生理作用,并对肌苷(inosine)增加腺苷的负性传导和负性变速作用进行了探索。方法:15例病人(女性7例,男性8例),年龄25～70岁(平均61岁),所有病人均能以电刺激诱发室上性心动过速。15例中有心房内折返2例、窦房结折返1例、房室结折返5例和经旁路逆向传导的房室折返性心动过速7例。电生理研究用四根电极导管经股静脉分别插入房室连接处、高位右心房、低侧位右心房、右心室尖部。高位右房和右室尖部的导管用于刺激,其它导管用于记录右房电图和希氏束电图。另一2极导管经肘前静脉插入冠状窦记录左房活动。
ATP treatment of supraventricular tachycardia has been reported as early as 1955. In recent years, some people on the paroxysmal supraventricular tachycardia infantile paroxysmal venous injection of ATP and compared with verapamil and digitalis, that ATP and verapamil is the first choice for rapid termination of paroxysmal supraventricular tachycardia. This article further explores the role of ATP-2Na in various types of paroxysmal supraventricular tachyarrhythmia sites, efficacy and electrophysiological effects on the presence of ventricular pacing in patients with ventricular pacing, and inosine increased adenosine negative Sex conduction and negative speed change were explored. Methods: Fifteen patients (7 females and 8 males) aged 25-70 years (average 61 years), all of whom could induce supraventricular tachycardia by electrical stimulation. Among the 15 cases, there were 2 cases of atrial reentry, 1 case of reentry sinoatrial node, 5 cases of atrioventricular nodal reentry and 7 cases of atrioventricular reentrant tachycardia reversed by bypass. Electrophysiology research with four lead through the femoral vein catheter inserted into the AV chamber, high right atrium, low right atrium, right ventricular apex. The upper right atrium and the right ventricular tip were used for stimulation, and the other catheters were used to record the right and the left radiogram. Another 2-pole catheter was inserted into the coronary sinus through the antecubital vein to record left atrial activity.