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为了研究神经激肽Ｂ（ＮＫＢ）可能的升压途径，用免疫荧光组织化学方法结合荧光金（ＦＧ）逆行追踪技术研究了下丘脑内神经激肽Ｂ受体（ＮＫＲ）阳性神经元向孤束核（ＮＴＳ）的投射。ＦＧ微量注射于ＮＴＳ后，ＦＧ逆标细胞主要分布于下丘脑背侧区、室旁核、穹窿周区、外侧区的背侧部和腹外侧部；而ＮＫＲ阳性细胞主要出现于下丘脑的背侧区、室旁核、穹窿周区、外侧区的中段、视上核和乳头体内侧核的内侧亚核。免疫荧光染色结果显示：双标神经元分布在下丘脑背侧区、穹窿周区、外侧区的背侧部和腹外侧部，主要为圆形或椭圆形的中型细胞。双标细胞占ＦＧ标记细胞总数的１１．２％、占ＮＫＲ阳性细胞总数的１１．９％。研究结果显示：下丘脑内部分ＮＫＲ阳性神经元投射至ＮＳＴ，这些投射神经元可能具有调节血压的作用。
In order to investigate the possible step-up pathways of neurokinin B (NKB), the expression of neurokinin B receptor (NKR) -positive neurons in the hypothalamus to the solitary tract Nuclear (NTS) projection. After microinjection of FG into NTS, FG retrograde cells mainly distributed in the dorsal hypothalamic area, paraventricular nucleus, perforninal area, dorsal area and ventral lateral part of lateral area, while NKR positive cells mainly appeared in the dorsal surface of hypothalamus Lateral zone, paraventricular nucleus, perforninal zone, medial segment of lateral zone, supraoptic nucleus of supraoptic nucleus and medulla nucleus. Immunofluorescence staining showed that double-labeled neurons distributed in the dorsal hypothalamus, the periventricular area, the dorsolateral part of the lateral area and the ventral part, mainly round or oval-shaped cells. Double labeled cells accounted for 11.2% of the total number of FG-labeled cells, accounting for 11.9% of the total number of NKR-positive cells. The results show that: Part of the hypothalamus NKR-positive neurons projecting to NST, these projection neurons may have the role of regulating blood pressure.