口服有效的抗真菌药酮康唑,可引起男子女性型乳房。现已证明,酮康唑是睾酮和肾上腺类固醇合成的强抑制剂。男子女性型乳房的主要原因可能是雌二醇/睾酮(E/T)比值增大。方法:4名健康男性,在24h内口服3片酮康唑(每片200mg)的前、后,测定血清睾酮、雌二醇和性激素结合球蛋白(SHBG)浓度。5例前列腺癌病人,每8h口服酮康唑 Oral and effective antifungal ketoconazole, can cause men’s female breast. It has been shown that ketoconazole is a potent inhibitor of testosterone and adrenal steroid synthesis. The main reason for a woman’s female breast may be an increase in the estradiol / testosterone (E / T) ratio. Methods: Four healthy men were tested for serum testosterone, estradiol and sex hormone binding globulin (SHBG) concentrations before and after oral administration of 3 ketoconazole (200 mg per tablet) within 24 hours. 5 cases of prostate cancer patients, oral ketoconazole every 8h