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目的探讨牛黄千金散对中枢的抑制作用。方法给小白鼠灌胃牛黄千金散 ,分别采用苯甲酸钠咖啡因和电刺激引起惊厥 ,观察牛黄千金散的对抗作用 ;加用戊巴比妥钠给小白鼠灌胃 ,药后15min内观察翻正反射消失作为催眠指标 ;加用可待因给小白鼠灌胃 ,用扭体法观察小白鼠的镇痛作用 ;牛黄千金散小白鼠灌胃 ,用抖笼法观察对小白鼠自发活动的影响。结果牛黄千金散对药物和电刺激引起的惊厥均有对抗作用 ,并能加强戊巴比妥钠的催眠作用 ;加强可待因的镇痛作用 ;对小白鼠自发活动也有一定的抑制作用 ,与生理盐水对照组比较有非常显著的差异(P<0.01)。结论牛黄千金散有明显的中枢抑制作用。
Objective To investigate the inhibitory effect of Niuhuang Qianjin Powder on the central nervous system. Methods The mice were treated with Niuhuang Qianjin powder by gavage, and the convulsions caused by sodium benzoate and caffeine were used respectively to observe the antagonistic effect of Niuhuang Qianjin Powder. The mice were given intragastric administration with sodium pentobarbital, and the rats were observed and reconstructed within 15 min after drug administration. The disappearance of reflex was used as a hypnosis indicator; plus codeine was given to mice, gavage, and the analgesic effect of the mice was observed by the writhing method; Niuhuang Qianjin scattered mice were gavaged and the effect of the shaking activity on the spontaneous activity of the mice was observed. RESULTS Niuhuangqinjin Powder had antagonistic effect on convulsions caused by drugs and electrical stimulation, and it could strengthen the hypnotic effect of pentobarbital sodium; it strengthened the analgesic effect of codeine; it also had a certain inhibitory effect on the spontaneous activity of mice. There was a very significant difference in the saline control group (P<0.01). Conclusion Niuhuang Qianjin Powder has obvious central inhibitory effect.