造血干细胞数量减少和功能异常是再生障碍性贫血(AA)的发病基础,其发病机制至今尚未阐明。除继发性从有确切的理化因素等诱因外,大多数从无明显诱因,其中70%~80%的AA发病涉及免疫调节机制的紊乱。随着对AA发病机制研究的不断深入,越来越多的研究表明AA是一种以造血组织为靶细胞 The number of hematopoietic stem cells and functional dysfunction is the basis of the pathogenesis of aplastic anemia (AA), the pathogenesis has not yet been elucidated. In addition to secondary factors such as the exact physical and chemical factors have the incentive, most from no obvious incentive, of which 70% to 80% of the AA pathogenesis involves immunomodulatory disorders. With the deepening of the study on the pathogenesis of AA, more and more studies have shown that AA is a hematopoietic tissue as a target cell