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目的研究阿魏酸在大鼠各肠各段的吸收动力学特征。方法采用大鼠在体肠回流实验装置,采用UV法和HPLC法分别测定肠循环液中酚红和阿魏酸的量。结果阿魏酸在大鼠小肠各段的吸收速率常数(ka)于阿魏酸不同质量浓度(20、50、100、200μg/mL)时分别为0.433 4、0.469 7、0.452 1、0.430 2-h 1;不同pH值7.8、6.8、5.4时分别为0.254 1、0.602 1、1.200 6-h 1;在不同肠段十二指肠、空肠、回肠、结肠时分别为0.151 2、0.178 4、0.168 7、0.066 9 h-1。结论药物质量浓度对ka无影响;在pH值为5.4~7.8,随药物溶液pH值的减小,药物ka显著增加;药物在十二指肠、空肠和回肠的吸收较好,在结肠的吸收较差;阿魏酸在肠道的吸收呈一级动力学过程,吸收机制为被动扩散。
Objective To study the absorption kinetics of ferulic acid in various intestinal segments of rats. Methods The rat intestine reflux experiment device was used to determine the amounts of phenol red and ferulic acid in intestinal circulatory fluids by UV and HPLC methods, respectively. Results The ferulic acid absorption rate constant (ka) in the rat small intestine was 0.433 4, 0.469 7, 0.452 1, 0.430 2- at different ferulic acid concentrations (20, 50, 100, 200 μg/mL). h 1; different pH values of 7.8, 6.8, and 5.4 were 0.254 1, 0.602 1, and 1.200 6-h 1, respectively; in the different duodenum, duodenum, jejunum, ileum, and colon, they were 0.1511 2, 0.178 4, and 0.168 respectively. 7, 0.066 9 h-1. Conclusion The drug concentration has no effect on ka; at pH 5.4-7.8, the drug ka increases significantly with the decrease of the pH value of the drug solution; the drug absorbs better in the duodenum, jejunum and ileum, and is absorbed in the colon. It is poor; the absorption of ferulic acid in the intestine is a first-order kinetic process, and the absorption mechanism is passive diffusion.