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以青霉素、链霉素和阿维菌素为代表的微生物药物3次获得诺贝尔奖的青睐,凸显了微生物药物在治疗人类疾病、防治农业病害和修复生态环境中的重要作用。同时,病原生物抗药性的日趋严重、新型疾病的发生、节能减排高产的生产需求等呼唤新药物、新机理、新菌株、新工艺的药物创新和高效制造。旨在改变传统药物发现、研究、改造和生产模式,高通量筛选、沉默基因簇
Microbiological drugs such as penicillin, streptomycin and abamectin have won the Nobel Prize three times, highlighting the important role of microbial drugs in the treatment of human diseases, prevention and control of agricultural diseases and restoration of ecological environment. At the same time, the increasingly serious resistance of pathogenic organisms, the occurrence of new diseases, energy-saving emission reduction production demand calls for new drugs, new mechanisms, new strains, new technology, drug innovation and efficient manufacturing. Designed to change the traditional drug discovery, research, transformation and production patterns, high-throughput screening, silencing gene cluster