论文部分内容阅读
目的 探讨IL-6和TNF-α在膀胱癌的表达及相关性。方法 采用ELISA法对56例膀胱癌患者血清和尿液IL-6和TNF-α水平进行测定。结果 膀胱癌患者血清和尿液中IL-6和TNF-α水平与对照组有显著性差异(P<0.01),随肿瘤的分期升高而增加(P<0.01),而与膀胱癌病理分级无关(P>0.05)。同时,血清中IL-6和TNF-α水平呈正相关(P<0.01),而膀胱癌患者尿液中TNF-α水平与对照组无差异(P>0.05)。结论 IL-6和TNF-α在膀胱癌患者血清中的显著性表达、与临床分期的关系以及两者的正相关性,可作为判断膀胱肿瘤生物学活性的重要指标。
Objective To investigate the expression and correlation of IL-6 and TNF-α in bladder cancer. Methods The levels of IL-6 and TNF-α in serum and urine of 56 patients with bladder cancer were determined by ELISA. Results The levels of IL-6 and TNF-α in serum and urine of bladder cancer patients were significantly different from those in control group (P <0.01), and increased with the stage of tumor (P <0.01) Not related (P> 0.05). Meanwhile, there was a positive correlation between serum IL-6 and TNF-α levels (P <0.01). There was no significant difference in urinary TNF-α level between the two groups (P> 0.05). Conclusion The significant expression of IL-6 and TNF-α in the serum of patients with bladder cancer, the relationship with clinical stage and the positive correlation between IL-6 and TNF-α can be used as an important index to judge the biological activity of bladder cancer.