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目的探讨环氧合酶2(COX2)mRNA表达与卵巢浆液性肿瘤发生、发展的关系。方法采用RTPCR法检测中国医科大学附属第二医院2000年3月至2002年10月手术切除的62例卵巢浆液性肿瘤组织中COX2mRNA的阳性表达率及相对含量,并以9例正常卵巢组织作对照。结果卵巢浆液性癌中COX2mRNA的表达率及相对含量明显高于正常卵巢组织及卵巢良性浆液性肿瘤(P<005),且COX2mRNA的表达与临床分期、组织学分级、有无腹水及淋巴结转移无关。结论COX2mRNA的过高表达与卵巢癌的发生密切相关。
Objective To investigate the relationship between cyclooxygenase 2 (COX2) mRNA expression and the occurrence and development of ovarian serous tumors. Methods RTPCR was used to detect the positive expression rate and relative content of COX2 mRNA in 62 cases of ovarian serous tumors from March 2000 to October 2002 in the Second Affiliated Hospital of China Medical University. Nine cases of normal ovarian tissue were used as control . Results The expression and the relative content of COX2 mRNA in ovarian serous carcinoma were significantly higher than those in normal ovarian tissue and benign ovarian serous tumors (P <0.05). The expression of COX2 mRNA was not associated with clinical stage, histological grade, with or without ascites and lymph node metastasis . Conclusion Overexpression of COX2 mRNA is closely related to the occurrence of ovarian cancer.