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0前言在全球范围内,前列腺癌的发病率和病死率存在着巨大差异。该病在西方发达国家发病率最高,在非裔美国人群病死率最高,而在亚洲人群中发病率及病死率均为全球最低,提示不同人种在前列腺癌的遗传方面存在异质性。在欧美和日本人群中,全基因组关联研究(GWAS)技术已经被用于检测前列腺癌的遗传易感性位点,但至今尚无关于GWAS检测中国人群前列腺癌易感位点的报道。1资料和方法本研究联合国内多家泌尿外科研究中心,对4 484例病理确诊的前列腺癌患者和8 934名健康对照人群进行
0 Introduction There is a huge difference in the incidence and mortality of prostate cancer worldwide. The disease has the highest incidence in the western developed countries and the highest case fatality in the African American population. However, the morbidity and mortality in the Asian population are the lowest in the world, suggesting that heterogeneity exists in the genetic aspects of prostate cancer among different ethnic groups. In Europe, the United States and Japan, genome-wide association study (GWAS) technology has been used to detect genetic predisposition sites of prostate cancer, but so far there is no report about GWAS detection of susceptibility sites for prostate cancer in Chinese population. 1 Materials and Methods In this study, a total of 4 484 patients with pathologically diagnosed prostate cancer and 8 934 healthy controls were enrolled in the United Nations Multi-Urology Research Center