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英《柳叶刀》第Ⅰ卷第8159期(1980年)报道:A.Brugarolas等的研究已发现化合物四氢噻唑-4-羧酸(thioproline)作用于瘤细胞的细胞膜上,能使瘤细胞逆转为正常细胞。因此,作者等对晚期癌瘤病人用此化合物进行了研究。在有肺转移的头颈表皮样癌中,给予数剂量的thioproline后,获得一定的效果。组织学检查表明,瘤细胞退化,转变为低度恶性,癌变消失。作者之一Gosalvez研究了一组新的化合
The British “The Lancet”, Volume I, Issue 8159 (1980) reported: A. Brugarolas et al.'s study has found that the compound thioproline acts on the cell membrane of tumor cells and enables tumor cells to Revert to normal cells. Therefore, the authors used this compound for the study of advanced cancer patients. In the case of head and neck epidermoid carcinomas with lung metastases, several doses of thioproline are administered to obtain a certain effect. Histological examination showed that the tumor cells were degenerating and turned into low-grade malignant and cancerous. One of the authors, Gosalvez, studied a new set of combinations