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反复口服活性炭将增加许多药物的清除。给健康志愿者预服苯巴比妥200g后10、14、24、36和48小时,予以活性炭17 g,结果显示,苯巴比妥的平均消除半衰期,从110小时下降至20小时。有人用口服活性炭治疗2例急性苯巴比妥中毒患者发现,不仅消除半衰期降低(24小时以下),而且昏迷时间和所需的支持疗法亦减少。6例成人中重度苯巴比妥中毒患者,在首剂50～100g后,每4小时重复给予活性炭50 g。到12小时时,苯巴比妥的平均全身清除率为每分钟84 ml,
Repeated oral administration of activated carbon will increase the clearance of many drugs. At 10, 14, 24, 36 and 48 hours after pre-treatment with 200 g of phenobarbital, healthy volunteers were given 17 g of activated carbon and the mean elimination half-life of phenobarbital dropped from 110 to 20 hours. Some patients treated with oral activated charcoal in 2 patients with acute phenobarbital poisoning found not only to reduce the half-life reduction (24 hours), and coma time and the required supportive therapy is also reduced. Six adult patients with moderate to severe phenobarbital poisoning, after the first dose of 50 ~ 100g, repeated every 4 hours of activated carbon 50 g. By 12 hours, the mean systemic clearance of phenobarbital was 84 ml per minute,