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类风湿关节炎(RA)是一种累及周围关节为主的多系统性、炎症性自身免疫性疾病,RA患者滑膜内炎性细胞浸润和滑膜细胞增殖可导致关节软骨和骨质侵蚀性破坏,主要病机为T细胞介导的细胞免疫反应异常。环孢素可用于治疗活动性或难治性RA,作用机制可能通过抑制T淋巴细胞的活化和增殖。本文简要综述RA发病机制以及环孢素用于RA治疗的作用机制研究。
Rheumatoid arthritis (RA) is a multi-systemic, inflammatory autoimmune disease involving the surrounding joints. Inflammatory cell infiltration and synovial cell proliferation in the synovium of RA patients can lead to articular cartilage and bone erosion Destruction, the main pathogenesis of T cell-mediated cellular immune response abnormalities. Cyclosporine can be used for the treatment of active or refractory RA, the mechanism may be through the inhibition of T lymphocyte activation and proliferation. This article briefly reviewed the pathogenesis of RA and the mechanism of action of cyclosporine in the treatment of RA.