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采用流式细胞分析术(FCM)检测15例正常子宫内膜组织与28例子宫内膜癌组织的DNA含量与细胞周期分布,并由此推算出DNA指数(DI)和S期细胞比率(SPF),结合雌、孕激素受体检测结果,从分子生物学角度对子宫内膜癌的生物学特性进行了研究。15例正常子宫内膜组织均为二倍体,其DI为0.93～1.07,而28例子宫内膜癌中二倍体有18例(64％),异倍体出现率与组织分化程度及受体状况密切相关(P均<0.05),SPF亦与分化程度相关。
Flow cytometric analysis (FCM) was used to detect the DNA content and cell cycle distribution in 15 cases of normal endometrium and 28 cases of endometrial carcinoma, and then the DNA index (DI) and S phase cell ratio (SPF ), Combined with estrogen and progesterone receptor test results, from the molecular biology point of view of the biological characteristics of endometrial cancer. 15 cases of normal endometrial tissue were diploid, the DI was 0.93 ~ 1.07, and 28 cases of endometrial cancer in 18 cases (64%), the occurrence of aneuploidy and the degree of tissue differentiation and The body condition was closely related (P <0.05). SPF also correlated with the degree of differentiation.