慢性乙型肝炎是严重威胁人类健康的疾病,多种核苷(酸)类似物如拉米夫定、阿德福韦酯等长期广泛应用于抗乙型肝炎病毒感染,有效地抑制病毒复制,但随着应用时间延长,其较高的耐药率也受到了广泛的关注。替诺福韦酯2008年被批准用于慢性乙型肝炎的抗病毒治疗,并显示了良好的疗效。多项研究证实,替诺福韦酯在拉米夫定耐药者及阿德福韦酯耐药者均发挥了良好的抗病毒作用。 Chronic hepatitis B is a serious threat to human health diseases, a variety of nucleoside (acid) analogues such as lamivudine, adefovir dipivoxil long-term widely used in anti-hepatitis B virus infection, effectively inhibit the virus replication, However, as the application time prolongs, its high resistance rate has also received widespread attention. Tenofovir disoproxil was approved in 2008 for antiviral treatment of chronic hepatitis B and showed good efficacy. A number of studies have confirmed that tenofovir dipivoxil in lamivudine resistant and adefovir dipivoxil have played a good antiviral effect.