急性髓系白血病(AML)是常见的急性白血病,患者经治疗有可能治愈,但仍存在复发或继发难治性贫血的危险性。目前的治疗方案不良反应和毒副作用较大,进一步探求有效的治疗方案一直都是AML研究的热点。黑色素瘤分化相关基因-7(MDA-7)自被发现以来,研究显示其对各种肿瘤具有良好的诱导凋亡作用,同时无明显细胞毒性作用[1]。本研究通过构建重组腺病毒载体,增加病毒产率及目的基因表达,并研究产物 Acute myeloid leukemia (AML) is a common acute leukemia that patients may be cured after treatment, but there is still a risk of recurrent or secondary refractory anemia. The current treatment of adverse reactions and side effects, to further explore effective treatment programs have been AML research hot spots. Since its discovery, melanoma differentiation-related gene-7 (MDA-7) has been shown to induce apoptosis in various tumors with no significant cytotoxic effects [1]. In this study, by constructing recombinant adenovirus vector, increase the virus yield and gene expression, and study the product