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目的 探讨联合诊断方法 ,以提高幽门螺杆菌 (helicobacter pylori,Hp)感染的诊断敏感性和特异性。方法 2 5 9例胃镜检查患者除作组织病理检查外 ,在胃窦部取 3块胃粘膜分别作细菌培养、快速尿素酶试验、组织涂片染色。结果 检测方法中以细菌培养阳性率为最高 [76.19% (175 / 2 5 9) ];快速尿素酶试验次之 [5 8.3 % (15 1/ 2 5 9) ];组织涂片染色最低 [5 1.7% (13 4/ 2 5 9) ];后 2项与细菌培养相比有显著性差异。以 3种方法平行检测为金标准 ,细菌培养敏感性为 87.1% (175 / 2 0 1) ,快速尿素酶试验为 75 .1% (15 1/ 2 0 1) ,组织涂片染色 66.7% (13 4/ 2 0 1) ;两两平行检测的敏感性 :细菌培养加快速尿素酶试验为 99.5 % (2 0 0 / 2 0 1) ,细菌培养加组织涂片染色为 89.6% (180 / 2 0 1) ,快速尿素酶试验加组织涂片染色为 85 .1% (171/ 2 0 1)。结论 平行检测可提高 Hp感染诊断敏感性 ,细菌培养加快速尿素酶试验是提高 Hp感染诊断敏感性的一个较理想的组
Objective To investigate the diagnostic methods to improve the diagnostic sensitivity and specificity of helicobacter pylori (Hp) infection. Methods Twenty-five patients with endoscopy were divided into three groups: gastric culture, rapid urease test and tissue smear staining, except for histopathological examination. Results The positive rate of bacterial culture in the test was the highest [76.19% (175/259)]; the rapid urease test was the second [53.3% (15 1/259)]; the tissue smear staining was the lowest 1.7% (13 4/259)]. The latter 2 items were significantly different from those of bacterial cultures. The sensitivity of bacterial culture was 87.1% (175/201), rapid urease test was 75.1% (15/1/20), tissue smear staining was 66.7% The sensitivity of parallel detection was 99.5% (200/21) for bacterial culture and 89.6% (180/2) for bacterial culture plus tissue smear 0 1), rapid urease test plus tissue smear staining was 85.1% (171/2 0 1). Conclusions The parallel detection can improve the diagnostic sensitivity of Hp infection. The bacterial culture accelerated urease test is an ideal group to improve the diagnostic sensitivity of Hp infection