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目的 :探讨妊娠期高血压应用硫酸镁联合硝苯地平治疗的效果。方法 :将2014年1月-2017年1月1000例妊娠期高血压患者作为研究对象随机原则分组,各纳入500例。单一治疗组单纯用硫酸镁治疗,联合治疗组应用硫酸镁联合硝苯地平治疗。比较两组妊娠期高血压治疗效果;母婴结局;干预前后患者舒张压以及收缩压水平。结果 :联合治疗组妊娠期高血压治疗效果高于单一治疗组,P<0.05;联合治疗组母婴结局优于单一治疗组,P<0.05,其中,单一治疗组产后出血39例,新生儿窒息27例,而联合治疗组产后出血14例,新生儿窒息6例。干预前两组舒张压以及收缩压水平相近,P>0.05;干预后联合治疗组舒张压以及收缩压水平优于单一治疗组,P<0.05。结论 :妊娠期高血压应用硫酸镁联合硝苯地平治疗的效果确切,可有效改善患者血压水平,优化母婴结局,效果肯定,值得推广。
Objective: To investigate the effect of magnesium sulfate combined with nifedipine on gestational hypertension. Methods: One hundred and thousand cases of hypertensive patients with gestational hypertension from January 2014 to January 2017 were randomly divided into five groups. The single treatment group was treated with magnesium sulfate alone, and the combined treatment group was treated with magnesium sulfate and nifedipine. The effect of treatment on gestational hypertension was compared between two groups; maternal and infant outcome; diastolic blood pressure and systolic blood pressure were measured before and after intervention. Results: The treatment effect of pregnancy-induced hypertension was higher in the combined treatment group than in the single treatment group (P <0.05). The maternal and infant outcomes were better in the combined treatment group than in the single treatment group (P <0.05), of which 39 were postpartum hemorrhage, 39 were neonatal asphyxia 27 cases, and combined treatment group 14 cases of postpartum hemorrhage, 6 cases of neonatal asphyxia. Before intervention, diastolic blood pressure and systolic blood pressure were similar, P> 0.05. After intervention, the diastolic blood pressure and systolic blood pressure in the combination therapy group were better than those in the single therapy group (P <0.05). Conclusion: The application of magnesium sulfate combined with nifedipine in gestational hypertension has definite effect, which can effectively improve the blood pressure of patients and optimize the outcome of maternal and infant. The effect is worthy of promotion.