对１０例伴有肝脏转移的消化道癌进行了组织病理学、Ｌａｍｉｎｉｎ、Ｆｉ－ｂｒｏｎｅｃｔｉｎ免疫组化和粘液组化研究，发现消化道原发癌灶与肝脏转移癌灶的癌组织均呈团块状、巢状生长，组织学分化程度较高，原发灶Ｌａｍｉｎｉｎ和Ｆｉｂｒｏｎｅｃｔｉｎ多呈阳性。分布有极性肝转移灶阳性率降低，且分布极性消失或倒置。癌细胞多不具有粘液分泌功能。肝脏转移灶周边肝细胞呈Ｌａｍｉｎｉｎ强阳性反应。本文对癌细胞生物学行为特征与肝转移的关系进行了初步探讨。 Histopathology, Laminin, Fi-bronectin immunohistochemistry, and mucin histochemistry were performed in 10 cases of gastrointestinal cancers with hepatic metastases. The primary gastrointestinal cancer and liver metastases were found to be lumps. The morphology and nest growth showed a high degree of histological differentiation. The primary lesions were mostly Laminin and Fibronectin. The positive rate of positively distributed liver metastases decreased, and the polarity of the distribution disappeared or reversed. Most cancer cells do not have mucus secretion. Liver cells of liver metastases showed a strong Laminin positive reaction. In this paper, the relationship between the biological behavior of cancer cells and liver metastasis was discussed.