论文部分内容阅读
目的:观察冠心平对异丙肾上腺素(ISO)致大鼠心肌缺血的影响。方法:采取大鼠scISO(30mg·kg-1)致急性心肌缺血模型,观察冠心平对大鼠血清乳酸脱氢酶(LDH)、肌酸磷酸激酶(CK)、丙二醛(MDA)、超氧化物歧化酶(SOD)活性的影响;观察注射ISO后不同时间J点下降情况,心肌病理损伤程度的影响;结果:冠心平各剂量组均可不同程度降低LDH,CK活力降低血清MDA水平,升高SOD水平(P<0.01,P<0.05);明显抑制ISO引起的大鼠心电图J点下降(P<0.05,P<0.01);心肌病理损伤程度明显减轻。结论:冠心平对ISO致大鼠心肌缺血模型具有明显保护作用。
Objective: To observe the effects of Guanxinping on isoproterenol (ISO) -induced myocardial ischemia in rats. Methods: A rat model of acute myocardial ischemia induced by scISO (30 mg · kg -1) was used to observe the effect of Guanxinping on serum LDH, CK, MDA, (SOD) activity; observed at different times after injection of ISO J point decreased myocardial pathological damage; Results: Guanxinping dose groups can be reduced to varying degrees, LDH, CK activity decreased serum MDA levels , And increased SOD level (P <0.01, P <0.05). It significantly inhibited the decrease of J point of ISO induced electrocardiogram (P <0.05, P <0.01), and significantly reduced the degree of myocardial pathological injury. Conclusion: Guanxinping has a significant protective effect on ISO-induced myocardial ischemia in rats.