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目的观察疏肝和胃颗粒联合四联疗法对幽门螺杆菌(Hp)相关性慢性非萎缩性胃炎的治疗效果。方法 60例Hp相关性慢性非萎缩性胃炎患者,随机分为治疗组和对照组,各30例。治疗组给予疏肝和胃颗粒联合西药四联治疗,对照组给予安慰剂联合西药四联治疗,比较两组治疗后的症状改善情况以及Hp转阴率。结果治疗组临床症状改善总有效率均高于对照组(P<0.05);治疗组患者Hp转阴率为86.7%,明显高于对照组的73.3%(P<0.05)。结论疏肝和胃颗粒联合四联疗法治疗Hp感染的慢性非萎缩性胃炎疗效优于单纯四联疗法,可提高Hp转阴率,值得在临床推广使用。
Objective To observe the therapeutic effect of Shugan Hewei granule combined with quadruple therapy on Helicobacter pylori (Hp) -related chronic non-atrophic gastritis. Methods Sixty patients with Hp-related chronic non-atrophic gastritis were randomly divided into treatment group and control group, with 30 cases in each group. The treatment group was given Shugan and stomach granules combined with western medicine quadruple treatment, while the control group was given placebo combined with western medicine quadruple therapy. The improvement of symptoms and Hp negative conversion rate were compared between the two groups. Results The total effective rate of clinical symptom improvement in the treatment group was higher than that in the control group (P <0.05). The negative conversion rate of Hp in the treatment group was 86.7%, significantly higher than that in the control group (73.3%, P <0.05). Conclusion Shugan and stomach granules combined with quadruple therapy in the treatment of Hp infection of chronic non-atrophic gastritis is superior to the simple quadruple therapy, can increase the Hp conversion rate, it is worth in the clinical promotion and use.