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目的:探讨Survivin在宫颈鳞状上皮细胞癌(CSCC)和宫颈上皮内瘤变(CIN)组织中的阳性表达及相关性。方法:用免疫组织化学(IHC)SP法检测92例CSCC及癌旁正常宫颈组织和40例CIN组织中Survivin的蛋白表达情况,并对数据进行统计分析。结果:CSCC组中Survivin阳性表达率为78.26%(72/92),CINⅠ、CINⅡ和CINⅢ组分别为26.67%(4/15)、64.28%(9/14)和72.72%(8/11);正常宫颈鳞状上皮组织Sur-vivin阳性表达率为2.17%(2/92)。宫颈鳞癌组、CINⅡ、CINⅢ组Survivin的阳性表达明显高于CINⅠ组及正常宫颈组织,P<0.01;CINⅠ与CINⅡ、CINⅢ组之间Sur-vivin表达差异有统计学意义,P<0.05;Sur-vivin的表达在各组均与年龄无关。结论:Survivin的阳性表达与宫颈癌的进展、组织学分级和临床分期有关,而与年龄无关。宫颈癌临床分期越晚、细胞分化程度越低,Sur-vivin的阳性表达率越高。
Objective: To investigate the positive expression and correlation of Survivin in cervical squamous cell carcinoma (CSCC) and cervical intraepithelial neoplasia (CIN). Methods: Immunohistochemical (IHC) SP method was used to detect the protein expression of Survivin in 92 cases of CSCC, adjacent normal cervical tissues and 40 cases of CIN tissues, and the data were statistically analyzed. Results: The positive expression rates of Survivin in CSCC group were 78.26% (72/92), 26.67% (4/15), 64.28% (9/14) and 72.72% (8/11) in CIN Ⅰ, CIN Ⅱ and CIN Ⅲ groups respectively. The positive expression rate of Sur-vivin in normal cervical squamous epithelium was 2.17% (2/92). The positive expression of Survivin in cervical squamous cell carcinoma group, CINⅡ and CINⅢgroup was significantly higher than that in CINⅠgroup and normal cervical tissue, P <0.01; There was significant difference in Sur-vivin expression between CINⅠ and CINⅢgroup, P <0.05; Sur The expression of -vivin was independent of age in all groups. Conclusion: The positive expression of Survivin is related to the progress of cervical cancer, histological grade and clinical stage, but not age. The later clinical stage of cervical cancer, the lower the degree of cell differentiation, the higher the positive rate of Sur-vivin expression.