目的:调查克林霉素泌尿系统毒性反应发生的情况并分析相关因素,为临床合理用药提供参考。方法:对克林霉素所致的169例泌尿系统毒性反应文献进行分类统计与分析。结果:ADR病例的男女比例为1.4:1;56.8%的病例为老年人或未成年人;67.5%的病例用药不规范;97.0%的患者静滴给药;72.2%的病例使用本品的盐酸盐;45.0%单独用药,36.1%联合用药;临床表现以血尿和(或)蛋白尿为主(76.9%)。全部病例治愈或好转。结论:克林霉素可致泌尿系统毒性反应,严重者可致肾衰竭,使用时须慎重考虑年龄、用法用量、给药途径等相关因素,做到合理用药,减少不良反应的发生。 Objective: To investigate the incidence of clindamycin urinary system toxicity and analyze the related factors, to provide a reference for clinical rational drug use. Methods: 169 clindamycin-induced urinary tract toxicity literature classification and statistics. Results: The male-female ratio of ADR cases was 1.4: 1, 56.8% of cases were elderly or minors, 67.5% of cases were not standardized, 97.0% of patients were intravenously administered and 72.2% Acid salt; 45.0% alone, 36.1% combination; the main clinical manifestations were hematuria and / or proteinuria (76.9%). All cases cured or improved. Conclusion: Clindamycin can cause urinary system toxic reactions, severe cases can cause renal failure, use should be carefully considered age, usage dosage, route of administration and other related factors, so that rational use of drugs to reduce the incidence of adverse reactions.