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选取2012年8月~2014年8月我院收治的118例幽门螺杆菌阳性消化性溃疡患者。随机分为观察组和对照组各59例。观察组采取雷贝拉唑、甲硝唑、阿莫西林、丽珠得乐四联疗法治疗。对照组采取雷贝拉唑、甲硝唑、阿莫西林三联疗法治疗。治疗1w,观察两组患者临床疗效、不良反应发生情况;治疗结束1个月后,观察两组患者幽门螺杆菌根除情况。结果观察组患者治疗总有效率显著高于对照组,与对照组比较,差异具有统计学意义(P<0.05)。观察组患者幽门螺杆菌根除率显著高于对照组,与对照组比较,差异具有统计学意义(P<0.05)。两组不良反应发生情况比较,差异无统计学意义(P>0.05)。两组患者均未发生严重不良反应。采取雷贝拉唑、甲硝唑、阿莫西林、丽珠得乐四联疗法治疗治疗幽门螺杆菌感染阳性消化性溃疡,临床疗效佳,可有效改善患者幽门螺杆菌根除率,无严重不良反应发生,值得临床推广。
118 patients with Helicobacter pylori-positive peptic ulcer admitted to our hospital from August 2012 to August 2014 were selected. Randomly divided into observation group and control group of 59 cases. The observation group took rabeprazole, metronidazole, amoxicillin, Lizhu Dele quadruple therapy. The control group to take rabeprazole, metronidazole, amoxicillin triple therapy. After 1 week of treatment, the clinical efficacy and adverse reactions of the two groups were observed. One month after the end of treatment, H. pylori eradication was observed in both groups. Results The total effective rate of observation group was significantly higher than that of control group, the difference was statistically significant (P <0.05). The eradication rate of Helicobacter pylori in the observation group was significantly higher than that in the control group, the difference was statistically significant (P <0.05). Adverse reactions between the two groups, the difference was not statistically significant (P> 0.05). No serious adverse reactions occurred in both groups. Taking rabeprazole, metronidazole, amoxicillin, and bezolovate quadruple therapy for the treatment of positive H.pylori-positive peptic ulcer, clinical curative effect is good, can effectively improve the eradication rate of Helicobacter pylori in patients without serious adverse reactions Occurs, it is worth clinical promotion.