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用放射免疫法和硫代巴比妥酸荧光法分别检测了３６例慢性阻塞性肺病（ＣＯＰＤ）患者和ＣＯＰＤ并肺心病患者、１６例健康人的超氧化物歧化酶（ＳＯＤ）、雨二醛（ＭＤＡ）并同时采用改良的Ｂｏｙｕｎｎ法分离、固定淋巴细胞，对外周血淋巴细胞线粒体膜磷脂进行组织化学定位的研究。结果表明：ＣＯＰＤ和肺心病患者的不同病期与ＳＯＤ、ＭＤＡ、淋巴细胞线粒体数目及膜磷脂的改变有相关性，病程长、病情重，ＭＤＡ则升高，淋巴细胞线粒体数目增多，线粒体膜磷脂定位呈现不同程度的改变。提示：过氧化作用与ＣＯＰＤ和肺心病患者外周血淋巴细胞线粒体膜磷脂的改变有明显的相关性，可能是其影响细胞功能活动的靶部位。
Radioimmunoassay and thiobarbituric acid were used to detect the levels of superoxide dismutase (SOD), superoxide dismutase (SOD) and nitric oxide synthase in 36 patients with chronic obstructive pulmonary disease (COPD), COPD and cor pulmonale, (MDA). At the same time, the modified Boyunn method was used to separate and immobilize lymphocytes to study the histochemical localization of mitochondrial membrane phospholipids in peripheral blood lymphocytes. The results showed that COPD and pulmonary heart disease in patients with different stages of disease associated with SOD, MDA, the number of mitochondria and membrane phospholipid changes have a long course, severe illness, MDA increased, the number of mitochondria increased lymphocyte mitochondrial membrane phospholipid Positioning showed varying degrees of change. Tip: Peroxidation and COPD and patients with cor pulmonale of peripheral blood lymphocyte mitochondrial membrane phospholipid changes have a clear correlation, may affect the cell’s functional activity of the target site.