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目的观察婴儿巨细胞病毒(CMV)性肝炎的临床特点及更昔洛韦的治疗效果。方法回顾性分析36例住院CMV肝炎婴儿的临床特点,评价28例应用更昔洛韦治疗疗效及其不良反应。结果 CMV肝炎婴儿均有肝功能异常,表现为血清谷丙转氨酶(94.4%)、谷草转氨酶(91.7%)及γ-谷氨酰转肽酶(52.8%)不同程度的升高,总胆红素多为轻中度升高(30.6%)。部分患儿出现黄疸(25.0%)、肝脏肿大(25.0%)和脾脏肿大(8.3%)。易合并心肌损害(83.3%)、肺炎或支气管炎(38.9%)。更昔洛韦治疗后患儿症状缓解,肝功能指标均有不同程度的下降,不良反应轻。结论婴儿CMV肝炎大部分预后良好;更昔洛韦治疗婴儿CMV肝炎疗效肯定,安全性好。
Objective To observe the clinical features of infant cytomegalovirus (CMV) hepatitis and the therapeutic effect of ganciclovir. Methods The clinical features of 36 inpatients with CMV hepatitis were retrospectively analyzed. The efficacy and adverse reactions of ganciclovir in 28 patients were evaluated. Results All of the infants with CMV hepatitis had abnormal liver function. The serum levels of alanine aminotransferase (94.4%), aspartate aminotransferase (91.7%) and γ-glutamyl transpeptidase (52.8% More mild to moderate increase (30.6%). Some children had jaundice (25.0%), enlarged liver (25.0%) and enlarged spleen (8.3%). Easy to merge myocardial damage (83.3%), pneumonia or bronchitis (38.9%). Ganciclovir treatment of children with symptoms, liver function indicators have varying degrees of decline, adverse reactions. Conclusion Most of the patients with CMV hepatitis have a good prognosis. Ganciclovir is effective in treating infant CMV hepatitis with good safety.