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目的观察滋阴养血清热方治疗干燥综合征(pSS)的临床疗效。方法将64例女性pSS患者随机分为治疗组33例和对照组31例,对照组口服硫酸羟氯喹片,治疗组在对照组治疗基础上温服中药滋阴养血清热方,3个月为1个疗程,1个疗程后比较两组临床疗效及两组患者治疗后症状积分、唾液分泌量、泪液流量及免疫炎性指标的变化。结果治疗组总有效率为87.88%,对照组总有效率为64.52%,两组比较差异有统计学意义(P<0.05)。两组治疗后症状总积分、唾液分泌量、泪液流量均较本组治疗前有显著改善(P<0.05),且治疗组改善程度优于对照组(P<0.05)。两组治疗后C反应蛋白(CRP)、红细胞沉降率(ESR)、免疫球蛋白G、免疫球蛋白A、免疫球蛋白M均较本组治疗前有显著改善(P<0.05),且治疗组在降低CRP和ESR方面均较对照组有统计学差异(P<0.05)。结论滋阴养血清热方联合硫酸羟氯喹片治疗pSS较单纯使用硫酸羟氯喹片疗效更好。
Objective To observe the clinical efficacy of Ziyin Yangxue Qingre Fang in treating Sjogren’s syndrome (pSS). Methods Sixty-four female pSS patients were randomly divided into treatment group (n = 33) and control group (n = 31). The control group was orally given hydroxychloroquine sulfate tablets. The treatment group was given Wenzhong Yangxue Qingre Decoction One course of treatment and one course of treatment were compared between the two groups after treatment and the two groups of patients after treatment symptoms, saliva secretion, tear flow and immune inflammatory changes. Results The total effective rate was 87.88% in the treatment group and 64.52% in the control group, with significant difference between the two groups (P <0.05). The total symptom score, salivary secretion and tear flow in both groups were significantly improved after treatment (P <0.05), and the improvement in the treatment group was better than that in the control group (P <0.05). After treatment, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), immunoglobulin G, immunoglobulin A and immunoglobulin M were significantly improved in both groups (P <0.05) Compared with control group, CRP and ESR decreased significantly (P <0.05). Conclusion Ziyin Yangxue Qingre Decoction combined with hydroxychloroquine sulfate tablets in the treatment of pSS better than the simple use of hydroxychloroquine sulfate tablets.