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１９９４年底，在江苏省３个肾综合征出血热高发地区，分别进行了国产沙鼠肾Ⅰ型苗和地鼠肾Ⅱ型苗的大规模人群接种；一年后，用同一厂家同一型别的疫苗进行了一针次加强接种，并进行了四年期的免疫持久性和防病效果观察，结果显示：沙鼠肾Ⅰ型苗的中和抗体在加强后抗体阳性率最高，随后逐年下降，至免后４年（加强后３年），其中和抗体阳性率仍高于免后１年；地鼠肾Ⅱ型苗的中和抗体在基础三针免后，阳转率最高，一年后经一针次加强，阳性率大大提高，至免后４年（加强后３年），其阳性率仍高于免后１年。对各个不同时期两种型别疫苗的同期进行比较，Ⅰ型苗的免后荧光抗体阳性率高于Ⅱ型苗，而中和抗体阳性率，则为Ⅱ型苗高于Ⅰ型苗。２种型别的疫苗在四年观察期间，接种人群共发生４例病人，有３例发生于免后１年内，此４例病人的血清学型别均不与所接种疫苗的型别相同，这些结果提示，免后１年加强接种是必要的，两种疫苗均有较好的防病效果，尤其对同型病例的保护率达１００％，二种疫苗的保护期至少４年。另外，通过对全程接种者免后３年流行高峰前后的荧光抗体波动，和对接种与对照人群发生的病例的病情进行比较研究，显示，国产两种型别的ＨＦＲＳ灭活疫苗免后无免疫效果（感染）增强反应。
By the end of 1994, three large-scale population vaccination of domestic gerbil kidney type I vaccine and hamster kidney type II vaccine were carried out in three areas of high incidence of hemorrhagic fever with renal syndrome in Jiangsu Province. One year later, the same type of Vaccines were vaccinated one time, and the four-year immune persistence and disease prevention results showed that: Nephropathy type I vaccine gerbils kidney antibody positive rate after the highest, and then decreased year by year, After 4 years of exemption (3 years after the strengthening), the positive rate of neutralizing antibody was still higher than that of the 1 year after the immunization. Neutralizing antibody of hamster kidney type Ⅱ seedlings had the highest positive conversion rate after one year After a shot to strengthen the positive rate greatly increased to 4 years after the exemption (3 years after the strengthening), the positive rate is still higher than 1 year after the exemption. Compared with the two types of vaccines in different periods, the positive rate of type I vaccine was higher than that of type II vaccine, but the positive rate of type II vaccine was higher than that of type I vaccine. Two types of vaccines During the four-year observation period, there were 4 patients in the vaccinated population and 3 in one year after the immunization. The serological types of the 4 patients were not the same as those vaccinated, These results suggest that it is necessary to intensify vaccination one year after immunization. Both vaccines have good disease-prevention effects, especially the protection rate of 100% for the same type of cases and the two vaccines for at least 4 years. In addition, by comparing the fluctuation of fluorescent antibody before and after the post-3-year peak-to-peak post-vaccination and the incidence of cases in control and inoculation groups, it shows that both domestic and imported HFRS inactivated vaccines are immune-free Effect (infection) enhances response.