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[目的]评价关苍术粗粉、超微粉及水煎剂对小鼠的急性毒性.[方法]采用改良寇氏法测定关苍术粗粉及超微粉半数致死量;采用最大给药量法测定关苍术水煎剂最大给药量,并对关苍术进行毒理学评价.[结果]小鼠关苍术粗粉急性经口LD50为24.91g/kg;关苍术超微粉急性经口LD50为28.53g/kg;关苍术水煎剂最大给药量为生药495g/kg(生药量),相当于关苍术成人(体质量以60kg计)每日口服剂量以10~30g计算,小鼠最大耐受量是人用药剂量的约990~2 970倍.[结论]关苍术水煎剂为无毒药物.
[Objective] To evaluate the acute toxicities of Gynura divaricata powder, superfine powder and decoction on mice. [Method] The half dose lethal dose of Gansu herb and superfine powder was determined by Modified Kou’s method. Atractylodes macrocephala rhizome was administrated with the maximum dose of Atractylodes macrocephala decoction and toxicological evaluation of Atractylodes macrocephala was given. [Results] The acute oral LD50 of mice with Atractylodes macrocephala was 24.91g / kg; the acute oral LD50 of Atractylodes macrocephala was 28.53g / kg ; The maximum dose of Guancaizhu decoction is 495g / kg (crude drug) of crude drug, which is equal to that of Guan Atractylodes (body weight is 60kg), the daily oral dose is 10 ~ 30g, the maximum tolerable dose in mice is human Dosage of about 990 ~ 2970 times. [Conclusion] Guanzhong decoction is non-toxic drugs.