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The authors describe 12 pregnancies in women with epilepsy using lamotrigine (LTG) monotherapy. A seizure increase in nine pregnancies was probably related to a gradual decline of LTG level to dose ratio to 40% of baseline. After delivery, LTG kinetics returned swiftly to baseline, causing toxic side effects in some women. Frequent LTG level monitoring and appropriate dose adjust ents are advised in the period before and during pregnancy and after delivery, especially in women on LTG monotherapy.
The authors describe 12 pregnancies in women with epilepsy using lamotrigine (LTG) monotherapy. A seizure increase in nine pregnancies was probably related to a gradual decline of LTG level to dose ratio to 40% of baseline. After delivery, LTG kinetics returned swiftly to baseline , causing toxic side effects in some women. Frequent LTG level monitoring and appropriate dose adjust ents are advised in the period before and during during and after delivery, especially in women on LTG monotherapy.