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目的分析染色体多态变异与生殖异常的相关临床效应。方法对1096例遗传咨询患者常规制备外周血淋巴细胞,经G显带,进行染色体核型分析。结果检出异常核型102例,其中染色体多态变异63例,占被检总人数5.75%。结论染色体多态与患者生殖异常,不孕不育,自然流产,死胎,少弱或无精子症等具有一定相关性。在进行遗传咨询,优生优育中应引起重视,对提高临床诊治工作有重要意义。
Objective To analyze the clinical effect of chromosome polymorphism and reproductive abnormalities. Methods 1096 cases of genetic counseling patients routine preparation of peripheral blood lymphocytes, G banding, chromosome karyotype analysis. Results There were 102 cases of abnormal karyotype detected, of which 63 cases were polymorphic, accounting for 5.75% of the total. Conclusions Chromosomal polymorphisms are associated with genital abnormalities in patients, infertility, spontaneous abortion, stillbirth, oligozoospermia or azoospermia. In the genetic counseling, eugenics should pay attention to improve the clinical diagnosis and treatment work of great significance.