论文部分内容阅读
在剑麻皂甙元资源利用的研究中,改进了从剑麻皂甙元合成去脂舒(1,降血脂药)与安律酮(2,抗心律失常药)的工艺方法。通过安律酮衍生物的合成与生物活性的研究,发现了酰胺化合物3不仅毒性显著下降,并显示耐缺氧的活性。为了寻找疗效优于安律酮的新化合物,采用从剑麻皂甙元制得的表雄酮为原料,合成了16-氨基-17-羟基-5α雄甾-3β-醇的四个立体异构体4,它们的结构与构型均经波谱测试,元
In the research of the resource utilization of sisaloid saponin, the process of synthesizing dexamethasone (1, lipid-lowering drug) and anti-arrhythmic drug (2, antiarrhythmic drug) from sisal saponin was improved. By the study of the synthesis and biological activity of anthrone derivatives, it was found that not only did the amide compound 3 show a significant decrease in toxicity, but also show hypoxia-tolerant activity. In order to find a new compound with superior curative effect to antiendone, four stereoisomers of 16-amino-17-hydroxy-5α-androsta-3β-ol were synthesized by using eprostenone obtained from tigogenin Body 4, their structure and configuration have been tested by spectroscopy