论文部分内容阅读
目的 研究急性白血病患儿反复应用重组粒细胞集落刺激因子 (rhG CSF)的药代动力学及其与临床的关系。方法 应用酶联免疫吸附测定 (ELISA)方法检测 46例白血病患儿的血清G CSF浓度。结果 获得 2 9例患儿用rhG CSF后的标本 ,其血清G CSF浓度为 (5 335± 5 5 97) μg/L。反复应用rhG CSF的患儿在下次用药前血清G CSF水平恢复正常 ;少数未应用rhG CSF患儿可检测到较高浓度的G CSF。血清G CSF浓度与粒细胞绝对计数值呈负相关 (r=- 0 8746 ,P <0 0 1)。结论 rhG CSF的药代动力学中存在有粒细胞介导的清除机制 ,反复应用无药物蓄积作用
Objective To study the pharmacokinetics of recombinant human granulocyte colony-stimulating factor (rhG CSF) in children with acute leukemia and its relationship with clinical practice. Methods Serum G CSF concentration was measured in 46 children with leukemia by enzyme-linked immunosorbent assay (ELISA). Results A total of 29 children with rhG CSF were obtained. The serum G CSF concentration was (5 335 ± 5 5 97) μg / L. Serum G CSF levels returned to normal before repeated administration of rhG CSF in children. A small number of children without rhG CSF could detect higher concentrations of G CSF. Serum G CSF concentration was negatively correlated with absolute neutrophil count (r = - 0 8746, P <0.01). Conclusion There are granulocyte-mediated clearance mechanisms in the pharmacokinetics of rhG CSF, and repeated application of drug-free accumulation