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汉坦病毒是由啮齿类动物传播的一种负链RNA病毒,可致人类肾综合征出血热和汉坦病毒肺综合征(HPS)。HPS典型临床经过分4期,即:发热期、心肺(病变)期、多尿期和恢复期。安第斯病毒(ANDV)是汉坦病毒属中的一种,在阿根廷的一次爆发流行中已有证据表明,ANDV可发生人与人之间的传播。在智利的研究也已提示,ANDV感染有家庭群集现象。目前对该病前驱期的临床及实验室指征,如病毒血症或免疫反应知之甚少。本文首次报道在未出现临床症状之前,从HPS或肾综合征出血热患者的体内分离出汉坦病毒。
Hantavirus is a negative-strand RNA virus transmitted by rodents that causes hemorrhagic fever with human renal syndrome and Hantavirus pulmonary syndrome (HPS). HPS typical clinical sub-4, namely: fever, cardiopulmonary (disease), polyuria and convalescent. Andevirus (ANDV) is a member of the genus Hantavirus and evidence of an outbreak in Argentina indicates that ANDV can spread from person to person. Research in Chile has also suggested that ANDV infection has a familial cluster phenomenon. Current clinical and laboratory indications for the prodromal stage of the disease, such as viremia or immune response, are poorly understood. This paper reports for the first time that Hantaan virus was isolated from HPS or from patients with hemorrhagic fever with renal syndrome prior to the onset of clinical symptoms.