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目的:比较不同血清学检测方法诊断梅毒效用。方法:取204例确诊梅毒患者作为病例组,208例全面体检健康者为对照组,分别以联袂免疫吸附试验(enzyme 1inked immunosorbent assay,ELISA)、梅毒螺旋体明胶凝集试验(treponema pallidum particle agglutination,TPPA)、胶体金快速检测实验(SYP)、梅毒螺旋体凝集实验(treponema pallidum hemagglutination assay,TPHA)、甲苯胺红不加热血清反应素试验(toluidine red unheated-serum test,TRUST)进行检测。结果:TRUST病例组与一期梅毒阳性率低于SYP,SYP低于ELISA、TPPA、TPHA,差异具有统计学意义(P<0.05);TRUST诊断三期、隐性梅毒阳性率低于SYP、ELISA、TPPA、TPHA,差异具有统计学意义(P<0.05)。结论:ELISA、TPPA、TPHA均可作为理想的梅毒血清检验方法,SYP也可用于隐性梅毒诊断。
Objective: To compare different serological tests to diagnose syphilis. Methods: Totally 204 patients with confirmed syphilis were selected as the case group and 208 healthy controls were enrolled in the study. Enzyme-linked immunosorbent assay (ELISA), treponema pallidum particle agglutination (TPPA) , Colloidal gold rapid test (SYP), treponema pallidum hemagglutination assay (TPHA) and toluidine red unheated-serum test (TRUST). Results: The positive rates of TRUST cases and primary syphilis were lower than those of SYP and SYP, but lower than that of ELISA, TPPA and TPHA (P <0.05) , TPPA, TPHA, the difference was statistically significant (P <0.05). Conclusion: ELISA, TPPA, TPHA can be used as ideal syphilis serum test methods, SYP can also be used for diagnosis of latent syphilis.