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目的 :研究p16抑癌基因蛋白和增殖细胞核抗原PCNA与子宫内膜癌的关系。方法 :应用免疫组化SP法对 6 4例子宫内膜癌、2 2例非典型增生内膜、30例正常内膜做p16和PCNA检测。结果 :p16在内膜癌中检出率为46 87% ,正常内膜为 10 0 % ,P <0 .0 1。PCNA在内膜癌中弱阳性 (+) 2 3例 ,强阳性 ( ) 33例。p16和PCNA两者呈明显负相关。P <0 .0 1。结论 :p16和PCNA参与细胞周期调控 ,与子宫内膜癌的发生密切相关。
OBJECTIVE: To study the relationship between p16 tumor suppressor gene protein and proliferating cell nuclear antigen PCNA and endometrial carcinoma. Methods: The immunohistochemical SP method was used to detect p16 and PCNA in 64 cases of endometrial carcinoma, 22 cases of atypical hyperplastic endometrium and 30 cases of normal endometrium. Results: The positive rate of p16 was 46 87% in endometrial carcinoma and 100% in normal endometrium, P <0.01. PCNA in the endometrial cancer weak positive (+) 23 cases, strong positive () 33 cases. There was a clear negative correlation between p16 and PCNA. P <0 .0 1. Conclusion: p16 and PCNA are involved in cell cycle regulation and are closely related to the occurrence of endometrial cancer.