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[目的]探讨血清脂联素(APN)与冠心病(CHD)的相关性。[方法]从2006年1月～2009年12月选取28例稳定型心绞痛(SAP)和32例急性动脉综合征(ACS),60例造影阴性作为对照,进行血清APN测定,比较SAP,ACS和对照组血清生化指标及APN水平。经Logistic回归分析低APN血症是否是CHD的危险因素。[结果]SAP组和ACS组的超重、高血压、吸烟和饮酒与对照组比较有统计学差异(P﹤0.05)。SAP和ACS组APN,TC,TG,LHD-C,HDL-L及FBG与对照组比较差异有统计学意义(P﹤0.05)。Logistic回归分析发现APN是CHD的保护因素,TC和FBG是CHD的危险因素,OR值分别为0.67(0.55～0.94),3.01(1.72～5.69)和1.55(1.13～1.96)。[结论]APN是CHD的保护因素,APN可与血糖,血脂等冠心病危险因素一样作为临床常规检查指标,对冠心病及其程度具有预测的作用。
[Objective] To explore the correlation between serum adiponectin (APN) and coronary heart disease (CHD). [Methods] From January 2006 to December 2009, 28 patients with stable angina pectoris (SAP) and 32 patients with acute arterial syndrome (ACS) were selected and 60 patients with negative contrast were selected as control. The control group serum biochemical indicators and APN levels. Logistic regression analysis of whether low APN hyperlipidemia is a risk factor for CHD. [Results] Overweight, hypertension, smoking and alcohol consumption in SAP group and ACS group were significantly different from those in control group (P <0.05). The levels of APN, TC, TG, LHD-C, HDL-L and FBG in SAP and ACS group were significantly different from those in control group (P <0.05). Logistic regression analysis showed that APN was the protective factor of CHD. TC and FBG were risk factors of CHD. OR values were 0.67 (0.55-0.94), 3.01 (1.72-5.69) and 1.55 (1.13-1.96), respectively. [Conclusion] APN is a protective factor of CHD. APN can be used as a routine clinical examination index as coronary heart disease risk factors such as blood glucose and blood lipids, and has a predictive effect on coronary heart disease and its extent.