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目的:观察黄芪颗粒内服对乳腺癌术后患者生活质量及无进展生存期的影响。方法:选取112例已实施乳腺癌根除手术的患者,随机分为对照组和治疗组,2组均给予常规的抗肿瘤药物治疗,治疗组在此基础上加服黄芪颗粒,2组患者均连续治疗16周。观察2组患者近期疗效、生活质量及无进展生存期。结果:近期疗效总有效率对照组37.5%,治疗组53.6%,2组近期疗效总有效率比较,差异有显著性意义(P<0.05)。对照组在躯体功能和总体生活质量方面较治疗前有差异(P<0.05),治疗组则所有观察项目均较治疗前有差异(P<0.05);治疗组在躯体功能、情绪功能、认知功能及总体生活质量方面的改善程度与对照组比较,差异有显著性意义(P<0.05);对照组无进展生存期为(5.5±1.2)月,治疗组为(8.5±1.4)月,2组比较,差异有显著性意义(P<0.05)。结论:黄芪颗粒内服用于乳腺癌术后患者的治疗,可提高临床治疗效果,改善患者的生活质量,延长无进展生存期。
Objective: To observe the effect of Astragalus Granules on quality of life and progression-free survival of postoperative patients with breast cancer. Methods: One hundred and twelve patients who underwent radical mastectomy for breast cancer were randomly divided into control group and treatment group. Both groups were given conventional anticancer drug treatment. On the basis of this, the treatment group received Astragalus membranaceus, and both groups were continuous Treatment for 16 weeks. The short-term efficacy, quality of life and progression-free survival in two groups were observed. Results: The total effective rate in the short term was 37.5% in the control group and 53.6% in the treatment group. There was significant difference in the total effective rate between the two groups in the short term (P <0.05). The control group had a difference in body function and overall quality of life before treatment (P <0.05), and all the observation items in the treatment group were significantly different from those before treatment (P <0.05). In the treatment group, the body function, emotion function, cognition (5.5 ± 1.2) months in the control group, (8.5 ± 1.4) months in the treatment group, and (8.5 ± 1.4) months in the treatment group compared with that in the control group (P <0.05). There was no significant difference in the improvement of function and overall quality of life between the two groups The difference was significant (P <0.05). Conclusion: The oral administration of astragalus granules for postoperative patients with breast cancer can improve the clinical effect, improve the quality of life of patients and prolong the progression-free survival.