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目的评价3种抗逆转录病毒药物方案预防艾滋病母婴传播的效果。方法为2004-2015年云南省临沧市临翔区所发现的HIV感染孕产妇提供抗病毒药物预防母婴传播,同时为感染孕产妇及所生儿童提供随访服务,并为HIV感染孕产妇所生儿童提供早期诊断或于18月龄提供HIV抗体检测,以判断儿童的感染状态。分析294对HIV孕产妇及所生儿童单一抗病毒药物方案、二联和三联抗病毒药物方案预防艾滋病母婴传播的效果。结果临产时口服单一NVP方案42例,儿童感染4例,婴儿感染率为9.52%,孕28周后开始口服AZT+NVP二联方案23例,婴儿感染1例,感染率为4.35%。孕早期开始口服AZT+3TC+NVP/EFV/LPV/r 229例,婴儿感染1例,感染率为0.44%。结论孕早期采用三联抗病毒药物方案预防艾滋病母婴传播效果显著。
Objective To evaluate the efficacy of three antiretroviral regimens in preventing mother-to-child transmission of HIV. Methods HIV-infected pregnant women found in Linxiang District, Lincang City, Yunnan Province, from 2004 to 2015, provided antiviral drugs to prevent mother-to-child transmission and provide follow-up services to infected pregnant women and their children. HIV-infected pregnant women Children provide early diagnosis or HIV antibody testing at 18 months of age to determine the child’s status. Analyze 294 the effects of single antiviral drug programs for HIV for pregnant women and their children, dual and triple antiviral drug programs to prevent mother-to-child transmission of HIV. Results 42 cases of single oral NVP during laboring, 4 cases of children infected, the rate of infant infection was 9.52%. After 28 weeks of pregnancy, oral AZT plus NVP combined with 23 cases, 1 case of infantile infection, the infection rate was 4.35%. In early pregnancy, oral administration of 229 cases of AZT + 3TC + NVP / EFV / LPV / r, 1 case of infant infection, the infection rate was 0.44%. Conclusion The triple antiretroviral drug regimen in early pregnancy is effective in preventing mother-to-child transmission of AIDS.