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目的:观察姜延胶囊的抗炎镇痛作用。方法:采用醋酸致小鼠腹腔毛细管通透法、二甲苯致小鼠耳廓肿胀法、滤纸性肉芽肿法及小鼠热板法、扭体法镇痛实验等动物模型,考察姜延胶囊的抗炎镇痛效果。结果:姜延胶囊能明显减轻小鼠腹腔毛细血管通透性,对小鼠耳肿胀及肉芽肿均有抑制作用;并能减少热板及醋酸所致的小鼠疼痛反应,提高小鼠痛阈值。结论:姜延胶囊具有良好的抗炎镇痛作用,该实验为其临床应用提供了药理学依据。
Objective: To observe the anti-inflammatory and analgesic effect of Jiang Yan capsule. Methods: Animal models such as acetic acid-induced peritoneal capillary permeability, xylene-induced auricle swelling in mice, filter-paper granuloma and mouse hot-plate method and writhing analgesia were used to investigate the effects of Jiang Yan Capsule Anti-inflammatory analgesic effect. Results: Jiang Yan Capsule can significantly reduce the peritoneal capillary permeability of mice, mouse ear swelling and granuloma were inhibited; and can reduce hot plate and acetic acid-induced pain response in mice to increase the pain threshold in mice . Conclusion: Jiang Yan capsule has good anti-inflammatory and analgesic effects. This experiment provides a pharmacological basis for its clinical application.