糖尿病(DM)发病率及糖耐量异常人群在发达国家一直呈上升趋势,DM对人类健康的主要威胁来自于其合并症。近来的研究表明应激激活信号转导通路———核转录因子(NF-κB)、促细胞分裂剂激活性蛋白激酶(mitogen-actioted pro-tein kinase,P38MAPK)和N端Jun激酶/应激激活的蛋白激酶( The incidence of diabetes mellitus (DM) and impaired glucose tolerance in people in developed countries has been on the rise, DM’s main threat to human health from its complications. Recent studies have shown that stress-activated signal transduction pathways - nuclear transcription factor (NF-κB), mitogen-activated protein kinase (mitogen-actioted kinase) (P38MAPK) and N-terminal Jun kinase / Activated protein kinase (