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目的 :了解人类表皮生长因子 (hEGF)与胃粘膜完整性的关系。方法 :用放免法检测正常人、慢性浅表性胃炎 (活动期 )、消化性溃疡 (活动期 )、消化性溃疡 (愈合期 )等四组病人血、尿、胃液中的hEGF含量。结果 :慢性浅表性胃炎 (活动期 )和消化性溃疡 (活动期 )病人上述三种体液中的hEGF含量明显低于正常人和消化性溃疡 (愈合期 )病人 (P <0 .0 5 ) ,而正常人与消化性溃疡 (愈合期 )病人的hEGF含量无明显差别 (P >0 .0 5 )。结论 :说明hEGF与胃肠道粘膜的完整性有密切关系。
Objective: To understand the relationship between human epidermal growth factor (hEGF) and gastric mucosal integrity. Methods: The contents of hEGF in blood, urine and gastric juice were measured by radioimmunoassay in four groups of normal subjects, chronic superficial gastritis (active stage), peptic ulcer (active stage) and peptic ulcer (healing stage) Results: The content of hEGF in the three body fluids of patients with chronic superficial gastritis (active stage) and peptic ulcer (active stage) was significantly lower than that of the normal and peptic ulcer patients (P <0.05) , While the hEGF content of normal and peptic ulcer patients (healing period) had no significant difference (P> 0.05). Conclusion: This shows that hEGF is closely related to the integrity of gastrointestinal mucosa.