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目的探讨非糖尿病冠心病患者糖化血红蛋白(HbA1c)水平与颈动脉病变的相关性。方法选择经冠脉造影明确诊断冠心病的非糖尿病患者275例,按照HbA1c水平以三分位法分为低水平组(HbA1c≤5.6%,n=103例),中水平组(HbA1c:5.6%-5.9%,n=93例),高水平组(HbA1c>5.9%,n=79例)。颈动脉超声测定颈总动脉内膜中膜厚度(IMT),分为正常对照组(IMT≤0.9mm),轻度增厚组(IMT0.9mm-1.2mm),明显增厚组或斑块形成组(IMT>1.2mm)。分析HbA1c水平与颈动脉病变的相关性。结果 HbA1c高水平组中IMT>1.2mm者共56例,占70.9%,比例大于中水平组(64例,占68.8%),大于低水平组(67例,占65%),但无统计学意义。经Pearson相关分析及偏相关分析,校正年龄、性别、吸烟状况、饮酒状况、心梗史、病变支数、空腹血糖、尿酸、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、高敏C反应蛋白、BMI(体重指数)等因素后,HbA1c水平与颈动脉内中膜及斑块厚度无显著关系。结论在非糖尿病的冠心病人群中,HbA1c水平与颈动脉内中膜及斑块厚度无明显相关性。
Objective To investigate the relationship between HbA1c level and carotid artery disease in non-diabetic patients with coronary heart disease. Methods A total of 275 non-diabetic patients with coronary artery disease (CHD) diagnosed by coronary angiography were selected. HbA1c level was divided into low level group (HbA1c≤5.6%, n = 103) and middle level group (HbA1c: 5.6% -5.9%, n = 93), high-level group (HbA1c> 5.9%, n = 79). The common carotid intima-media thickness (IMT) was measured by carotid ultrasonography and divided into normal control group (IMT≤0.9mm), mild thickening group (IMT0.9mm-1.2mm), thickening group or plaque formation Group (IMT> 1.2 mm). Analysis of HbA1c levels and carotid artery disease correlation. Results There were 56 cases (70.9%) with high IMT> 1.2mm in HbA1c high level group, accounting for more than the middle level group (64 cases, 68.8%) and higher than the low level group (67 cases, 65% significance. Correlation analysis by Pearson and partial correlation analysis showed that age, gender, smoking status, drinking status, history of myocardial infarction, lesion count, fasting blood glucose, uric acid, triglyceride, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein Cholesterol, high-sensitivity C-reactive protein, BMI (body mass index) and other factors, HbA1c levels and carotid intima-media thickness and plaque no significant relationship. Conclusion There is no significant correlation between HbA1c level and carotid intima-media thickness and plaque thickness in non-diabetic CHD patients.