纤维蛋白原(Fg)及其与冠状动脉粥样硬化性心脏病(CHD)的关系是近年来研究的热点。流行病学资料已经证实,Fg与CHD存在显著相关性。但Fg在CHD不同类型的患者之间是否存在差异以及与冠状动脉病变的关系,还缺乏足够的临床验证。国内有关血浆Fg高水平与CHD发病率、严重程度关系的研究较多,但研究的结果尚不一致。本文就Fg的一般性质及其与CHD的关系及进展予以综述。 Fibrinogen (Fg) and its relationship with coronary atherosclerotic heart disease (CHD) is a hot topic in recent years. Epidemiological data have confirmed that there is a significant correlation between Fg and CHD. But Fg in different types of patients with CHD whether there are differences between and coronary artery disease, but also the lack of sufficient clinical validation. There are many studies about the relationship between the high level of plasma Fg and the incidence and severity of CHD in China. However, the results of the study are not consistent. This article reviews the general nature of Fg and its relationship with CHD and its progress.