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目的观察米非司酮治疗子宫内膜异位症的疗效及对患者个体氧化应激状态的影响。方法将63例子宫内膜异位症患者纳入研究中,均使用米非司酮进行治疗。结果应用米非司酮治疗后,总有效率为88.89%。同时治疗前后比较,发现患者同治疗前相比,机体MDA明显降低;GPx、AOA显著升高(P<0.05)。结论米非司酮治疗,可使患者体内脂质过氧化水平显著降低,抗氧化水平回升,通过缓解氧化应激损伤,控制病情,获得良好疗效。其可成为药物治疗子宫内膜异位症损伤的新机制之一。
Objective To observe the curative effect of mifepristone on endometriosis and its effect on oxidative stress in patients. Methods 63 cases of endometriosis were included in the study, both of which were treated with mifepristone. Results After mifepristone treatment, the total effective rate was 88.89%. At the same time, the levels of MDA were significantly decreased and the levels of GPx and AOA were significantly increased in the patients before and after treatment (P <0.05). Conclusion Mifepristone treatment can significantly reduce the level of lipid peroxidation in patients with anti-oxidation level rise, by alleviating the oxidative stress injury, control the disease and obtain good curative effect. It can be one of the new mechanisms of drug treatment for endometriosis injury.