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目的 采用Meta分析方法评价微创手术及开放手术对于先天性膈疝的治疗效果.方法 计算机检索Pubmed、Cochrane、Medline相关文献,检索时间为2006年1月至2016年7月.根据纳入标准查找有关对比微创手术及开放手术对先天性膈疝的治疗效果的文献,由2名评价者独立选择研究、提取数据和评估方法学质量后,采用RevMan 5.3软件对文献数据进行Meta分析.结果 最终共纳入15项研究,共纳入病例数4907例.开放手术在以下方面优于微创手术,差异有统计学意义:总复发率(RR 2.6995%CI[1.73,4.18]);使用补片修补的亚组分析中,仍可降低复发率(RR 3.86,95%CI[2.12,7.00]);手术时间(MD 56.42,95%CI[45.15,67.68]).但在随访时间大于1年的亚组分析中,复发率无统计学差异.微创手术在以下方面优于开放手术,其差异有统计学意义:术后并发症的发生率(RR 0.70,95%CI[0.51,0.97]);术后死亡率(RR 0.15,95%CI[0.07,0.34]);住院时间(MD 9.39,95%CI[4.32,14.46]);完全肠内营养时间(MD 0.81,95%CI[0.18,1.44]);术后机械通气时间(MD 1.78,95%CI[0.53,3.03]).结论 与开放手术相比,微创手术治疗先天性膈疝术后复发率较高、手术时间较长,但术后死亡率及并发症发生率较少.微创手术组的住院时间、完全肠内营养时间及术后机械通气时间均短于开放手术组.“,”Objective To compare the outcomes of mini -invasive surgery (MIS)versus open surgery for congenital diaphragmatic hernia (CDH). Methods The literatures comparing the outcomes of open sur-gery and MIS for CDH in databases of Pubmed,Cochrane and Medline were searched from January 2006 to July 2016.Studies were screened,data extracted and methodological qualities assessed by two independent review-ers.Meta -analyses were performed by RevMan 5.3. Results A total of 15 eligible studies involving 4907 patients were included.Open surgery was superior in the following aspects with significant differences:total re-currence rate (RR 2.69,95%CI[1.73,4.18]);in sub-group of patch use,it still decreased recurrence rate (RR 3.86,95%CI[2.12,7.00]);operative duration (MD 56.42,95%CI[45.15,67.68]).But in sub -group of follow-up time over 1 year,no statistically significant difference existed in recurrence rate.MIS was superior in the following aspects with statistical differences:occurrence rate of postoperative complications (RR 0.70,95%CI[0.51,0.97]);postoperative mortality (RR 0.15,95%CI[0.07,0.34]);hospitalization stay (MD 9.39,95%CI[4.32,14.46]);total enteral nutrition time (MD 0.81,95%CI[0.18,1.44]);postoperative ventilation time (MD 1.78,95%CI[0.53,3.03]). Conclusions As compared with open sur-gery,despite a higher recurrence rate and a longer operative duration,MIS can lower postoperative occurrences of mortality and complications.Meanwhile,hospitalization time,total enteral nutrition time and postoperative ventilation time are also shorter.