格子样角膜变性(Ⅰ型)是一种常染色体显性遗传性疾病,临床特征为基质层的网状条纹,上皮下及前部基质的雾状混浊。病变进展可伴有复发性上皮脱落及视力障碍。对视力严重减退者,穿透性角膜移植术是一种选择性治疗。但移植片内可能复发变性改变。作者对61例格子样角膜变性作穿透性角膜移植的眼作了回顾性研究。本文包括39例61次穿透性角膜移植术(移植及再移植)。移植片多为7mm,间断缝合,线结暴露。手术后6周及12周各拆除一半缝线。手术后并发症极少。作者发现13例23眼的29只移植片及再植片(48％)复发格子样角膜变性改变。手术后至复发的平均间隔为9年(3—26年)。大多数复发 Lattice-like corneal degeneration (type I) is an autosomal dominant genetic disorder characterized by reticular striation of the stroma, haze of the subendothelial and anterior stroma. Lesions may be associated with recurrent epithelial shedding and visual impairment. Penetrating keratoplasty is a selective treatment of patients with severe vision loss. However, the recurrence of degeneration may change within the graft. The authors retrospectively reviewed 61 cases of lattice-like corneal degeneration that had penetrated keratoplasty. This article includes 39 cases of 61 penetrating keratoplasty (transplant and replantation). Transplantation mostly 7mm, interrupted suture, knot exposed. Six weeks and 12 weeks after surgery, half of the sutures were removed. Very few complications after surgery. The authors found that 29 of 23 patients (23 eyes) had recurrent plaque-like corneal degeneration with 29 implants and replantings (48%). The average interval from surgery to recurrence is 9 years (3- 26 years). Most relapse