胰升糖素样肽-1是由内分泌细胞分泌的胰岛素促泌素。近年发现胰升糖素样肽-1受体与其细胞表面特异受体结合后,可激活促进细胞增生和抗细胞凋亡的信号转导途径,诱导β细胞增生,抑制β细胞凋亡,从而对维持甚至增加β细胞量和改善β细胞功能起重要作用。因此,胰升糖素样肽-1有望成为治疗糖尿病的新药物靶点。 Glucagon-like peptide-1 is an insulin secretagogue secreted by endocrine cells. In recent years, it was found that glucagon-like peptide-1 receptor binding to its cell-surface specific receptor can activate signal transduction pathways that promote cell proliferation and anti-apoptosis, induce β-cell proliferation and inhibit β-cell apoptosis, Maintaining even an increase in beta cell mass and improving beta cell function play an important role. Therefore, glucagon-like peptide-1 is expected to become a new drug target for the treatment of diabetes.